November 2024

Alternating electric fields can improve chemotherapy treatment efficacy in blood cancer cell U937 (non-adherent cells)

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Revolutionary strides in cancer treatment are unfolding through innovative methods. A recent study has unveiled a promising approach by combining alternating electric fields with the with the antineoplastic drug, CAS 20830-81-3, showcasing enhanced efficacy in treating blood cancer cells, particularly the non-adherent U937 cells. This cutting-edge technique selectively targets dividing cancer cells while sparing normal […]

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A phase 3, open-label, randomized LUNAR study comparing Tumor Treating Fields therapy combined with standard systemic treatment versus standard systemic treatment alone in metastatic non-small-cell lung cancer patients who have experienced progression during or after platinum-based therapy.

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Advancements in alternating electric fields can significantly improve the survival rates of patients with metastatic non-small cell lung cancer (mNSCLC) who have not responded to platinum-based chemotherapy. This study shows that combining alternating electric field therapy with standard-of-care treatments can lead to better outcomes compared to standard-of-care treatments alone.

A phase 3, open-label, randomized LUNAR study comparing Tumor Treating Fields therapy combined with standard systemic treatment versus standard systemic treatment alone in metastatic non-small-cell lung cancer patients who have experienced progression during or after platinum-based therapy. Read More »

Research Progress on the Mechanism of Anti-Tumor Immune Response Induced by TTFields

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The article reviews the progress of research on the mechanism of anti-tumor immune response induced by Tumor Treating Fields (TTFields). TTFields has been approved for the treatment of glioblastomas and malignant pleural mesotheliomas. It highlights that TTFields have shown promising effects as a monotherapy and in combination with chemotherapy, but the underlying mechanisms through, which

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The distinguishing electrical properties of cancer cells

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This paper explores the unique electrical properties of cancer cells, shedding light on the complex network of factors that contribute to the development of cancer. It challenges thetraditional view of cancer as solely a genetic disease and emphasizes the importance of understanding the electrostatic changes in cancer cells compared to normal cells. By exploring the

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The combination of Electric Fields therapy with the drug repurposing strategy CUSP9v3 triggers metabolic reprogramming and produces synergistic anti-glioblastoma effects in vitro.

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This paper demonstrate multimodal treatment approach combining electric fields and the drug repurposing strategy CUSP9v3 shows promising results in enhancing the anti-glioblastoma activity. The study provides evidence of the synergistic effects of electric fields and CUSP9v3 in inhibiting the growth and migration of glioblastoma cells. Additionally, the combination treatment was associated with the suppression of

The combination of Electric Fields therapy with the drug repurposing strategy CUSP9v3 triggers metabolic reprogramming and produces synergistic anti-glioblastoma effects in vitro. Read More »

Electric Fields therapy in patients with glioblastoma: Long-term survival results in Germany in routine clinical care (TIGER) study.

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Electric Fields therapy has demonstrated significant improvements in overall survival (OS) and progression-free survival (PFS) when applied with adjuvant CAS 85622-93-1 compared to CAS 85622-93-1 alone in newly diagnosed glioblastoma (ndGBM). Electric Fields therapy delivers electric fields, through scalp-placed arrays, that disrupt cellular processes critical for cancer cell viability, is CE marked for WHO grade 4 glioma,

Electric Fields therapy in patients with glioblastoma: Long-term survival results in Germany in routine clinical care (TIGER) study. Read More »

Electric fields enhance the cytotoxic degranulation of natural killer cells in their attack against cancer cells.

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The study by Mylod et al. (2024) investigates the effects of electric fields, a non-invasive treatment using low-intensity, intermediate-frequency alternating electric fields, on natural killer (NK) cells and their ability to target glioblastoma (GBM) cells. The researchers found that electric fields, particularly at 200 kHz, significantly enhanced NK cell degranulation, a marker of cytotoxicity, against

Electric fields enhance the cytotoxic degranulation of natural killer cells in their attack against cancer cells. Read More »

Therapy using alternating electric fields for the treatment of solid tumors.

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This paper provides an extensive overview of electric fields technology, particularly its application in treating glioblastoma multiforme (GBM). Electric fields therapy is a non-invasive treatment that employs low-intensity, intermediate-frequency alternating electric fields to disrupt cancer cell division, leading to cell death while sparing normal cells. The therapy is administered through a wearable device, which patients

Therapy using alternating electric fields for the treatment of solid tumors. Read More »

The potential therapeutic application of tumor treating fields for malignant brain tumors.

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GBM is among the most lethal and challenging cancers due to their high recurrence rates and resistance to conventional therapies. Despite advancements in surgery, chemotherapy, and radiation, the prognosis for GBM remains dismal, with a median survival of only 15 months and a 5- year survival rate below 5%. This highlights the urgent need for

The potential therapeutic application of tumor treating fields for malignant brain tumors. Read More »

Positive Electrostatic Therapy for Metastatic Tumors: Targeted Induction of Apoptosis in Cancer Cells Using Pure Electric Charges (Cancer Medicine)

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Key Findings: Selective Apoptosis: The study demonstrated that Positive Electrostatic Charges (PECs) could selectively induce apoptosis in breast cancer cell lines, including MCF-7 (hormone receptor-positive breast cancer) and MDA-MB-468 (triple-negative breast cancer) cells. The therapy showed significant reductions in cell viability, while normal breast epithelial cells (MCF-10A) were not adversely affected, highlighting the selectivity of

Positive Electrostatic Therapy for Metastatic Tumors: Targeted Induction of Apoptosis in Cancer Cells Using Pure Electric Charges (Cancer Medicine) Read More »