The combination of Electric Fields therapy with the drug repurposing strategy CUSP9v3 triggers metabolic reprogramming and produces synergistic anti-glioblastoma effects in vitro.

This paper demonstrate multimodal treatment approach combining electric fields and the drug repurposing strategy CUSP9v3 shows promising results in enhancing the anti-glioblastoma activity. The study provides evidence of the synergistic effects of electric fields and CUSP9v3 in inhibiting the growth and migration of glioblastoma cells. Additionally, the combination treatment was associated with the suppression of oxidative phosphorylation, a key feature of cancer cell metabolism. These findings suggest that the multimodal approach may offer a potential strategy for improving treatment outcomes for glioblastoma patients. The study also highlights the need for further research and potential transition to the clinical setting.