October 2025

Non-contact electric fields’ effect on TNF-a in glioblastoma cell line: An experimental study

The experimental findings demonstrate that the non-contact electric field successfully triggers key cellular responses in the U87-MG glioblastoma cell line. Specifically, there was a visible increase of Tumor Necrosis Factor alpha (TNF-\alpha) after just 24 hours of exposure across all tested voltages (10, 30, and 50 Vpp). This initial surge is significant, as established electric […]

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Capacitance Electric Fields (CEFs) Represent a Groundbreaking Approach in Cancer Therapy

Capacitance Electric Fields (CEFs) uses the principles of physics to selectively target and disrupt cancer cells while sparing healthy tissues. Cancer cells are uniquely vulnerable due to their altered membranes, which have distinct electrical and structural properties compared to normal cells. By applying precisely controlled electric fields, CEFs destabilize these membranes, creating tiny, temporary pores

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Current Challenges in Cancer Therapy: A Biophysical Perspective on Electric Field-Based Strategies

Cancer treatment faces significant challenges due to tumor diversity, therapy resistance, immune system evasion, and toxicity. Conventional methods like chemotherapy, radiation, and immunotherapy are often limited by the tumor’s ability to adapt through genetic mutations and metabolic changes. The tumor microenvironment further complicates treatment by blocking drug penetration, suppressing immunity, and sustaining cancer stem cells,

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ECCT: Physical Therapy for Cancer – clinical report

国際抗老化再生医療学会雑誌 第 6 巻(20−33)2024By Shinichiro Akiyama, MD, PhD, FACPCancer gene; Immunotherapy ExpertClinical Oncology, McGill University, CANADAFaculty of Science and Technology, Keio University, JAPANMechanism of Action Electro Capacitive Cancer Therapy (ECCT) employs low-voltage, medium-frequency electric fields to disrupt mitotic progression by inducing microtubule depolymerization, ultimately triggering apoptosis in cancer cells while sparing normal tissues. By interfering

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Capacitance Electric Field Therapy: A New Frontier in Non-Invasive Cancer Treatment

This publication review explores the emerging cancer therapy modality known as Capacitance Electric Field (CEF), a non-invasive approach utilizing low-frequency alternating electric fields to selectively disrupt mitosis in tumor cells while sparing normal tissues. Through preclinical and early clinical studies, CEF has demonstrated tumor growth inhibition via multiple mechanisms including interference with microtubule polymerization, mitotic

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